San Francisco Giants vs New York Yankees Prediction, Preview and Odds - 04/12/2025

Game Time: 3:05 pm ET, Saturday, April 12, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  Fox Sports 1

DraftKings:  Moneyline odds:  Giants +114, Yankees -135; Over/Under:  8 runs

Bet365:  Moneyline odds:  Giants +115, Yankees -135; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Giants +115, Yankees -135; Over/Under:  8 runs

San Francisco Giants:  9-3 (2nd place, NL West)

New York Yankees:  7-5 (2nd place, AL East)

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San Francisco Giants:  8-2 last 10

New York Yankees:  5-5 last 10

The Giants are entering this series off a win but lost their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 9-3 record overall and have a road record of 5-1. This is the 2nd game of a 3-game series with the Yankees on Saturday with the series opener still to be played on Friday. Their offense ranks 15th in the MLB with a .692 OPS. Robbie Ray is their starting pitcher on Friday while Jordan Hicks is making his start in this game on Saturday. He is 1-0 with a 2.38 ERA this season. His team won their 2 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 2 HR, and 1 BB with 5 Ks on 6 hits through 5.1 IP against the Seattle Mariners.

The Yankees are entering this series off a win but lost their 3-game series against the Detroit Tigers 2-1 in their last series. They enter this game with a 7-5 record overall and have a home record of 4-2. This is the 2nd game of a 3-game series with the Giants on Saturday with the 1st game still to be played on Friday. Their offense ranks 1st in the MLB with a .855 OPS. Marcus Stroman is their starting pitcher on Wednesday while Will Warren is making his start in this game on Saturday. He is 0-0 with a 6.00 ERA this season. His team lost their 2 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 0 homers, and 1 BB with 5 strikeouts on 6 hits through 4 innings played against the Pittsburgh Pirates.

The current betting odds have the Giants listed as a slight underdog in this game according to Draftkings Sportsbook. The Giants have looked really good in their games this season with their 9-3 record overall which has them right near the top of the NL West with a good start to the season. They have also been a good road team with their 5-1 road record this year. Meanwhile, the Yankees have looked good in their games this season with their 7-5 record overall which has them right near the top of the AL East with a good start to the season. They have looked good in their own ballpark too with their 4-2 home record this season. The Yankees got off to a hot start this season and have one of the best offenses in the MLB, but lately they have been cooling off and just lost their last series against the Tigers. The Giants are also coming off a series loss and their offense hasn't been as good as the Yankees this season, but the pitching has been much better for the Giants. This is a game they have a better pitching matchup in too. The Giants are going with Hicks in this one and he has been good this season, coming off a decent start in his last one too. The Yankees are rolling with Warren and he hasn't looked as good this season. He has been giving up quite a few runs in his starts this year and just gave up 4 runs in his last start too. The Giants have been hot to start the season and they are in a really competitive division so they have the motivation to bounce back in this series and they can take advantage of the better pitching matchup too. The best way to place a bet here is on the Giants to win this game.

Giants Yankees Prediction:  Our MLB Pick for Saturday, April 12, 2025 (3:05 pm ET start time) is Giants 5 Yankees 4.

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San Francisco Giants: 168-167 (-14.2 units) on the moneyline in all games. 77-89 (-7.1 units) on the moneyline in road games. 120-121 (-11.4 units) on the moneyline against right-handed starters. 46-25 OVER as a road underdog of +100 to +150. 

New York Yankees: 103-84 (+12.9 units) on the moneyline when playing against a team with a winning record. 61-52 (+6.2 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 153-118 (+11.5 units) on the moneyline against right-handed starters. 10-4 OVER vs. NL teams allowing 4.0 or less runs/game on the season.

San Francisco Giants:  T. Murphy (C) Sixty Day IL - Back. J. Encarnacion (RF) Ten Day IL - Finger.

New York Yankees:  J. Brubaker (SP) Sixty Day IL - Ribs. J. Cousins (RP) Sixty Day IL - Elbow. D. LeMahieu (3B) Ten Day IL - Calf. S. Effross (RP) Fifteen Day IL - Hamstring. C. Beeter (SP) Fifteen Day IL - Shoulder. G. Stanton (DH) Ten Day IL - Elbow. C. Schmidt (SP) Fifteen Day IL - Rotator Cuff. J. Loaisiga (RP) Fifteen Day IL - Elbow. L. Gil (SP) Sixty Day IL - Back. G. Cole (SP) Sixty Day IL - Elbow.

“We’re going to make subtle moves -- you know, lefty and righty -- but I think Buster is trying to just create some stability here. So far, so good.” - Bob Melvin after his team’s win against the Reds in their game on Wednesday.

“I guess it’s just probably confirmed some things. I mean, he’s such a pro. His preparation. His attention to detail. His professionalism is off the charts. Then you look at him. This guy is probably on his way to the Hall of Fame, and he’s dripping in humility. The message with me is ‘whatever I need from him.’ It’s no, ‘I want to hit here. I want to play here.’ If it’s a day off, he’s ready. [He’s] going to play well for us between the lines but is going to elevate our room, too.” - Aaron Boone on Paul Goldschmidt after his team’s win against the Tigers in their game on Wednesday.

LaMonte Wade Jr. (L) 1B

Willy Adames (R) SS

Jung Hoo Lee (L) CF

Matt Chapman (R) 3B

Heliot Ramos (R) LF

Mike Yastrzemski (L) RF

Wilmer Flores (R) DH

Patrick Bailey (S) C

Tyler Fitzgerald (R) 2B

Ben Rice (L) DH

Aaron Judge (R) RF

Cody Bellinger (L) CF

Paul Goldschmidt (R) 1B

Jazz Chisholm Jr. (L) 2B

Anthony Volpe (R) SS

Jasson Domínguez (S) LF

J.C. Escarra (L) C

Oswaldo Cabrera (S) 3B

Batting Average:  Mike Yastrzemski (.344)

Hits:  Jung Hoo Lee (15)

Home Runs:  Wilmer Flores (5)

RBI:  Wilmer Flores (14)

Stolen Bases:  Tyler Fitzgerald (3)

Wins:  Robbie Ray (2)

Saves:  Ryan Walker (3)

ERA:  Hayden Birdsong (0.00)

Batting Average:  Paul Goldschmidt (.383)

Hits:  Paul Goldschmidt (18)

Home Runs:  Aaron Judge (6)

RBI:  Aaron Judge (20)

Stolen Bases:  Jazz Chisholm (4)

Wins:  Max Fried (2)

Saves:  Luke Weaver (1)

ERA:  Yoendrys Gómez (0.00)

Managers:

San Francisco Giants: Bob Melvin (2nd season)

New York Yankees: Aaron Boone (8th season)