San Francisco 49ers vs Arizona Cardinals Prediction, Preview and Odds - 01/05/2025

Game Time: 4:25 pm ET, Sunday, January 5, 2025

Venue:  State Farm Stadium, Glendale, AZ

Where to Watch:  FOX

DraftKings:  Point Spread:  49ers +4.5, Cardinals -4.5; Over/Under:  42.5 points

Bet365:  Point Spread:  49ers +4.5, Cardinals -4.5; Over/Under:  43 points

BetMGM:  Point Spread:  49ers +4, Cardinals -4; Over/Under:  42.5 points

San Francisco 49ers:  6-10 (4th place, NFC West)

Arizona Cardinals:  7-9 (3rd place, NFC West)

Do not miss out on our expert handicapper analysis! Jim Feist is on a HOT STREAK in the NFL on a 50-37-1 NFL RUN for +$8,580 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

San Francisco 49ers:  lost their last game at home against the Detroit Lions 40-34.

Arizona Cardinals:  lost their last game on the road against the Los Angeles Rams 13-9.

The 49ers are entering this game with a 6-10 record overall and they have a 1-4 record in their divisional games too. They are 4-5 in their home games, 2-5 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Detroit Lions 40-34. Brock Purdy was the starting QB and he completed 27/35 passes for 377 passing yards, 3 touchdowns, and 2 interceptions. Isaac Guerendo led the team in rushing yards with 34. Ricky Pearsall led the receivers with 141 receiving yards on 8 receptions and 1 TD. Isaac Yiadom led the defense in that game with 6 solo tackles and 1 assisted tackle while Nick Bosa led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

 

 

 

The Cardinals are entering this game with a 7-9 record overall and they have a 2-3 record in their divisional games too. They are 5-3 in their home games, 2-6 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Los Angeles Rams 13-9. Kyler Murray was the starting QB and he completed 33/48 passes for 321 passing yards, 1 touchdown, and 2 interceptions. Michael Carter led the team in rushing yards with 70. Trey McBride led the receivers with 123 receiving yards on 12 receptions and 1 TD. Kyzir White led the defense in that game with 4 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

The current betting odds have the 49ers listed as a 4.5 point underdog in this game according to Draftkings Sportsbook. The 49ers haven't looked good in their games this season with their 6-10 record overall which has them at the bottom of the NFC West and eliminated from playoff contention. They have had a really rough season with a lot of injuries to key players and it definitely derailed their season, but they have still been trying to fight in these games even though they have nothing left to play for. They are coming off a 40-34 loss to the Lions in their last one and their offense looked really good in that game. Meanwhile, the Cardinals haven't looked good in their games this season with their 7-9 record overall which has them in 3rd place of the NFC West and also eliminated from playoff contention. They were leading the division at one point and looked like a good team early on, but they collapsed after their bye week and their offense has looked terrible in a lot of their games lately. They had a chance to play spoiler with the Rams last week, but they lost 13-9 and had a chance to win the game right at the end, but Kyler Murray threw an INT in the end zone which ended the game. Neither team has anything to play for in this game as it is a meaningless game, but the Cardinals can't be trusted with the way they have played lately while the 49ers at least have some pride and have been showing fight in their games. The best way to place a bet here is on the 49ers to cover the spread in this game. 

49ers Cardinals Prediction:  Our NFL Pick for Sunday, January 5, 2025 (4:25 pm ET start time) is 49ers 27 Cardinals 13.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this San Francisco 49ers Arizona Cardinals prediction, be sure to drop by every day for our weekly NFL predictions and previews.

San Francisco 49ers: 1-5 ATS as an underdog. 3-6 ATS after a loss by 6 or less points. 7-18 ATS versus good offensive teams - averaging 5.65 yards/play or more. 3-0 OVER revenging a home loss against an opponent. 6-3 OVER after a loss by 6 or less points. 8-4 OVER versus good rushing teams - averaging 130 rushing yards/game or more.

Arizona Cardinals: 8-3 ATS off a loss against a division rival. 9-3 ATS after scoring 14 points or less last game. 19-13 ATS after 1 or more consecutive losses. 5-1 OVER as a home favorite of 7 points or less. 8-4 OVER after playing a division game. 11-4 OVER off a road loss. 6-1 OVER vs. bad defensive teams who give up 24 or more points/game.

San Francisco 49ers:  K. Juszczyk (FB) Injured - Illness. L. Floyd (DL) Injured - Shoulder. J. Elliott (DL) Injured - Knee. N. Bosa (DL) Injured - Hip. C. McKivitz (OL) Injured - Knee. T. Hufanga (SAF) Injured - Wrist. D. Winters (LB) Injured - Chest. T. Bethune (LB) Injured - Knee. D. Greenlaw (LB) Injured - Calf. R. Beal (DL) Injured - Ankle. A. Banks (OL) Injured - Knee. S. Burford (OL) Injured - Calf. J. Brown (SAF) Injured - Ankle. I. Guerendo (RB) Injured - Hamstring.

Arizona Cardinals:  J. Conner (RB) Questionable - Knee. E. Brown (OL) Questionable - Neck. B. Browning (OLB) Questionable - Neck. T. Benson (RB) Questionable - Ankle. M. Prater (K) Out - Knee. M. Wilson (LB) Injured - Concussion. J. Blount (SAF) Out - Ribs. D. Robinson (DL) Injured - Calf. M. Palardy (P) Injured - Illness. K. Beachum (OL) Injured - Rest.

“We weren’t able to slow them down enough on defense. That’s a real good offense, but we still have to slow them down a little bit more. That was the difference in the game. We had to win in it in a shootout. I thought the difference was our two turnovers.” - Kyle Shanahan after his team’s loss against the Lions in their last game. 

“The ball didn’t bounce our way. Got the ball at the end, thought we were going to win, and they made a good play. It stings because we’re there, but we’re not there. When we play our brand of ball, we can compete and beat everyone, but it doesn’t mean a lot.” - Jonathan Gannon after his team’s loss against the LA Rams in their last game. 

WR Samuel Sr., Deebo

WR Pearsall, Ricky

WR Jennings, Jauan

TE Kittle, George 

QB Purdy, Brock 

RB Guerendo, Isaac 

FB Juszczyk, Kyle

WR Wilson, Michael 

WR Harrison Jr., Marvin

WR Dortch, Greg 

TE McBride, Trey

QB Murray, Kyler 

RB Carter, Michael 

Passing: B. Purdy (3864)

Rushing: J. Mason (789)

Receiving: G. Kittle (1079)

Touchdowns: G. Kittle (8)

Passing: K. Murray (3609)

Rushing: J. Conner (1094)

Receiving: T. McBride (1081)

Touchdowns: J. Conner (9)

Coaches:

San Francisco 49ers: Kyle Shanahan (8th season)

Arizona Cardinals: Jonathan Gannon (2nd season)