Los Angeles Chargers vs Arizona Cardinals Prediction, Preview and Odds - 10/21/2024

by Rod Pearson

Friday, Oct 18, 2024
Game Time: 9:00 pm ET, Monday, October 21, 2024
Venue:  State Farm Stadium, Glendale, AZ 
Where to Watch:  ESPN+


Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  Chargers -2, Cardinals +2; Over/Under:  44 points
Bet365:  Point Spread:  Chargers -2, Cardinals +2; Over/Under:  44 points
BetMGM:  Point Spread:  Chargers -1.5, Cardinals +1.5; Over/Under:  44 points

Season Record

Los Angeles Chargers:  3-2 (2nd place, AFC West)
Arizona Cardinals:  2-4 (3rd place, NFC West)

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Recent Form
Los Angeles Chargers:  won their last game on the road against the Denver Broncos 23-16.
Arizona Cardinals:  lost their last game on the road against the Green Bay Packers 34-13.


Los Angeles Chargers vs Arizona Cardinals Preview and Analysis


The Chargers are entering this game with a 3-2 record overall and they have a 2-1 record in their divisional games too. They are 1-1 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Denver Broncos 23-16. Justin Herbert was the starting QB and he completed 21/34 passes for 237 passing yards, 1 touchdown, and 0 interceptions. J.K. Dobbins led the team in rushing yards with 96 and 1 TD. Simi Fehoko led the receivers with 44 receiving yards on 2 receptions. Alohi Gilman led the defense in that game with 6 solo tackles and 4 assisted tackles while Alohi Gilman and Morgan Fox each led the defense in sacks with 1. Elijah Molden came away with the only interception for them in that one.
 
 
 
The Cardinals are entering this game with a 2-4 record overall and they have a 2-0 record in their divisional games too. They are 1-2 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Green Bay Packers 34-13. Kyler Murray was the starting QB and he completed 22/32 passes for 214 passing yards, 1 touchdown, and 0 interceptions. Trey Benson led the team in rushing yards with 26. Trey McBride led the receivers with 96 receiving yards on 8 receptions. Krys Barnes led the defense in that game with 8 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. Sean Murphy-Bunting came away with the only interception for them in that one.


Chargers vs Cardinals Prediction

The current betting odds have the Chargers listed as a 2 point favorite in this game according to Draftkings Sportsbook. The Chargers have looked good in their games this season with their 3-2 record overall. Harbaugh has been taking over the culture of this team and they are heading in the right direction with him at the helm. Meanwhile, the Cardinals haven't looked great in their games this season with their 2-4 record overall. They are coming off another loss in their last one, losing on the road in Green Bay, and defense has been a major issue for this team. Their offense has looked good at times, but it has also been really up and down all season. Now they are going to play the Chargers who have a really good defense that hasn't been giving up many points and this is going to be another game which the Cardinals offense struggles in. The Chargers haven't had a great offense themselves, but they have been consistently putting up enough points to win games and their defense will be able to keep any leads they get too. The Cardinals are going to struggle a lot more on offense in this game and that is going to lead to another defensive win by the Chargers. The best way to place a bet here is on the Chargers to cover the spread in this game. 

Chargers Cardinals Prediction:  Our NFL Pick for Monday, October 21, 2024 (9:00 pm ET start time) is Chargers 21 Cardinals 10.
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NFL Betting Trends


Los Angeles Chargers: 8-4 ATS as a road favorite of 7 points or less. 7-4 ATS versus good rushing teams - averaging 4.5 rushing yards/carry or more. 15-6 1H ATS in road games. 9-3 1H ATS as a road favorite of 7 points or less. 4-0 1H OVER against NFC West division opponents. 11-6 1H OVER in all games where the total is between 42.5 and 49 points. 8-4 1H OVER after playing a division game.

Arizona Cardinals: 5-10 ATS when playing against a team with a winning record. 4-8 1H ATS as a home underdog of 7 points or less. 8-19 1H ATS in all games where the total is between 42.5 and 49 points. 12-6 OVER in home games. 10-4 OVER in a home game where the total is between 42.5 and 49 points. 10-2 OVER off a road loss. 

Key Injuries


Los Angeles Chargers:  J. Bosa (OLB) Injured - Hip. W. Dissly (TE) Injured - Shoulder. H. Hurst (TE) Injured - Groin. D. Chark (WR) Injured - Groin. K. Fulton (CB) Injured - Hamstring. J. Taylor (DB) Injured - Fibula. S. Fehoko (WR) Injured - Shoulder. T. Pipkins (T) Injured - Shoulder. Z. Johnson (G) Injured - Ankle. Q. Johnston (WR) Injured - Ankle. D. Leonard (DB) Injured - Hamstring. L. McConkey (WR) Injured - Hip.

Arizona Cardinals:  Z. Jones (WR) Injured - Hamstring. K. Beachum (OL) Injured - Hamstring. K. White (LB) Injured - Knee. S. Murphy-Bunting (CB) Injured - Neck. E. Brown (OL) Injured - Ankle. R. Lopez (DL) Injured - Ankle. M. Wilson (WR) Injured - Ankle. O. Pappoe (LB) Injured - Hip. G. Williams (CB) Injured - Groin. C. Jones (OL) Injured - Ankle. I. Adams (OL) Injured - Thumb. M. Harrison (WR) Injured - Concussion. D. Robinson (DL) Injured - Calf.

Notable Quotes


“I thought he was as precise as he could be, or a quarterback could be. There were some great throws, some great moves to avoid the pressure. He was just putting the ball in the appropriate spot throughout the entire game. I was super impressed. Hopefully this reminds everybody that Justin Herbert is really good at playing quarterback. He was putting it on the money.” - Jim Harbaugh after his team’s win against the Broncos in their last game. 


“We can’t play in a hole like that versus really good teams. It’s just too hard to overcome.” - Jonathan Gannon after his team’s loss against the Packers in their last game. 


Starting Lineups


Los Angeles Chargers
WR Johnston, Quentin
WR Palmer, Joshua
WR McConkey, Ladd
TE Hurst, Hayden 
QB Herbert, Justin 
RB Dobbins, J.K
FB Matlock, Scott 

Arizona Cardinals
WR Wilson, Michael 
WR Weaver, Xavier 
WR Dortch, Greg 
TE McBride, Trey
QB Murray, Kyler 
RB Conner, James 

Statistical Leaders


Los Angeles Chargers
Passing: J. Herbert (815)
Rushing: J. Dobbins (438)
Receiving: L. McConkey (219)
Touchdowns: Q. Johnston (3)

Arizona Cardinals
Passing: K. Murray (1186)
Rushing: J. Conner (403)
Receiving: M. Harrison (279)
Touchdowns: M. Harrison (4)

Coaches:
Los Angeles Chargers: Jim Harbaugh (1st season)
Arizona Cardinals: Jonathan Gannon (2nd season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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