Kansas City Chiefs vs San Francisco 49ers Prediction, Preview and Odds - 10/20/2024

by Rod Pearson

Thursday, Oct 17, 2024
Game Time: 4:25 pm ET, Sunday, October 20, 2024
Venue:  Levi's Stadium, Santa Clara, CA
Where to Watch:  FOX


Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  Chiefs +1.5, 49ers -1.5; Over/Under:  47 points
Bet365:  Point Spread:  Chiefs +1, 49ers -1; Over/Under:  47 points
BetMGM:  Point Spread:  Chiefs +1.5, 49ers -1.5; Over/Under:  47 points

Season Record

Kansas City Chiefs:  5-0 (1st place, AFC West)
San Francisco 49ers:  3-3 (1st place, NFC West)

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Recent Form
Kansas City Chiefs:  won their last game at home against the New Orleans Saints 26-13.
San Francisco 49ers:  won their last game on the road against the Seattle Seahawks 36-24.


Kansas City Chiefs vs San Francisco 49ers Preview and Analysis


The Chiefs are entering this game with a 5-0 record overall and they have a 1-0 record in their divisional games too. They are 3-0 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New Orleans Saints 26-13. Patrick Mahomes was the starting QB and he completed 28/39 passes for 331 passing yards, 0 touchdowns, and 1 interception. Kareem Hunt led the team in rushing yards with 102 and 1 TD. JuJu Smith-Schuster led the receivers with 130 receiving yards on 7 receptions. Nick Bolton led the defense in that game with 6 solo tackles and 5 assisted tackles while Tershawn Wharton led the defense in sacks with 1. Bryan Cook came away with the only interception for them in that one.
 
 
 
The 49ers are entering this game with a 3-3 record overall and they have a 1-2 record in their divisional games too. They are 2-1 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Seattle Seahawks 36-24. Brock Purdy was the starting QB and he completed 18/28 passes for 255 passing yards, 3 touchdowns, and 0 interceptions. Isaac Guerendo led the team in rushing yards with 99. Deebo Samuel Sr. led the receivers with 102 receiving yards on 3 receptions and 1 TD. Fred Warner led the defense in that game with 6 solo tackles and 5 assisted tackles while Sam Okuayinonu led the defense in sacks with 1. Renardo Green and Malik Mustapha each came away with 1 interception for them in that one.


Chiefs vs 49ers Prediction

The current betting odds have the Chiefs listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. The Chiefs have looked great in their games this season with their 5-0 record overall which has them leading the AFC West with the best record in the NFL. There are only 2 undefeated teams left in the NFL this season and the Chiefs are one of them. Now they are coming out of their bye week too so they have had extra time to prepare for this Super Bowl rematch. Meanwhile, the 49ers haven't looked great in their games this season with their 3-3 record overall which has them leading the NFC West at the moment. They have had a very rough start to the season after losing in the Super Bowl last year, and they are also really banged up with a lot of key players missing from the lineup. These two don't play each other often, but the Chiefs have been very good against the 49ers in their few meetings over the last few years. The Chiefs are also rested coming out of their bye week and Andy Reid has a really good record when coming out of a bye week. The Chiefs also have a very good record as an underdog over the last few seasons and they are still the Super Bowl champions who have started the season undefeated after 6 weeks, the 49ers aren't going to be the team in their condition to stop this Chiefs train. The best way to place a bet here is on the Chiefs to cover the spread in this game. 

Chiefs 49ers Prediction:  Our NFL Pick for Sunday, October 20, 2024 (4:25 pm ET start time) is Chiefs 27 49ers 24.
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NFL Betting Trends


Kansas City Chiefs: 5-0 ATS against NFC West division opponents. 7-1 ATS as an underdog. 8-1 ATS versus good rushing teams - averaging 130 rushing yards/game or more. 11-3 ATS in non-conference games. 7-3 OVER in a road game where the total is between 42.5 and 49 points. 13-7 1H OVER in road games. 8-3 1H OVER after allowing 14 points or less last game. 

San Francisco 49ers: 0-5 ATS against AFC West division opponents. 2-6 ATS in a home game where the total is greater than or equal to 45.5. 3-8 1H ATS off a road win. 8-3 OVER as a home favorite of 7 points or less. 8-4 OVER in non-conference games. 10-5 OVER versus good offensive teams - averaging 350 yards/game or more.

Key Injuries


Kansas City Chiefs:  D. Nnadi (DT) Injured - Triceps. M. Danna (DE) Injured - Pectoral. M. Hardman (WR) Injured - Knee. C. Edwards-Helaire (RB) Injured - Illness.

San Francisco 49ers:  T. Williams (OT) Injured - Rest. M. Collins (DL) Injured - Knee. L. Floyd (DL) Injured - Rest. C. Ward (CB) Injured - Knee. D. Flannigan-Fowles (LB) Injured - Calf. M. Wright (K) Injured - Shoulder. J. Elliott (DL) Injured - Knee. D. Samuel (WR) Injured - Wrist. J. Jennings (WR) Injured - Hip. J. Moody (K) Injured - Ankle. J. Mason (RB) Injured - Shoulder. D. Luter (CB) Injured - Pelvis. M. Mustapha (SAF) Injured - Ankle. R. Pearsall (WR) Injured - Chest.

Notable Quotes


“It was a great feeling to get back in the end zone. I missed it very much. That's why I threw up a heart. To show my love for Kansas City.” - Kareem Hunt after their win against the Saints in their last game. 


“When everyone's on point and we're doing our thing, we're a hard team to beat.” - Brock Purdy after their win against the Seahawks in their last game. 


Starting Lineups


Kansas City Chiefs
WR Watson, Justin
WR Worthy, Xavier
WR Smith-Schuster, JuJu
TE Kelce, Travis 
QB Mahomes, Patrick 
RB Hunt, Kareem

San Francisco 49ers
WR Aiyuk, Brandon
WR Samuel Sr., Deebo
WR Jennings, Jauan
TE Kittle, George
QB Purdy, Brock 
RB Guerendo, Isaac
FB Juszczyk, Kyle 

Statistical Leaders


Kansas City Chiefs
Passing: P. Mahomes (1235)
Rushing: K. Hunt (171)
Receiving: R. Rice (288)
Touchdowns: X. Worthy (4)

San Francisco 49ers
Passing: B. Purdy (1629)
Rushing: J. Mason (609)
Receiving: J. Jennings (404)
Touchdowns: G. Kittle (5)

Coaches:
Kansas City Chiefs: Andy Reid (12th season)
San Francisco 49ers: Kyle Shanahan (8th season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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