Detroit Lions vs Arizona Cardinals Prediction, Preview and Odds - 09/22/2024

Game Time: 4:25 pm ET, Sunday, September 22, 2024

Venue:  State Farm Stadium, Glendale, AZ

Where to Watch:  FOX

DraftKings:  Point Spread:  Lions -3, Cardinals +3; Over/Under:  51.5 points

Bet365:  Point Spread:  Lions -3, Cardinals +3; Over/Under:  51.5 points

BetMGM:  Point Spread:  Lions -3, Cardinals +3; Over/Under:  51.5 points

Detroit Lions:  1-1 (2nd place, NFC North)

Arizona Cardinals:  1-1 (2nd place, NFC West)

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Detroit Lions:  lost their last game at home against the Tampa Bay Buccaneers 20-16.

Arizona Cardinals:  won their last game at home against the Los Angeles Rams 41-10.

The Lions are entering this game with a 1-1 record overall and they have a 0-0 record in their divisional games too. They are 1-1 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Tampa Bay Buccaneers 20-16. Jared Goff was the starting QB and he completed 34/55 passes for 307 passing yards, 0 touchdowns, and 2 interceptions. Jahmyr Gibbs led the team in rushing yards with 84. Amon-Ra St. Brown led the receivers with 119 receiving yards on 11 receptions. Brian Branch led the defense in that game with 5 solo tackles and 1 assisted tackle while Aidan Hutchinson led the defense in sacks with 4.5. Brian Branch came away with the only interception for them in that one.

 

 

 

The Cardinals are entering this game with a 1-1 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Los Angeles Rams 41-10. Kyler Murray was the starting QB and he completed 17/21 passes for 266 passing yards, 3 touchdowns, and 0 interceptions. James Conner led the team in rushing yards with 122 and 1 TD. Marvin Harrison Jr. led the receivers with 130 receiving yards on 4 receptions and 2 TDs. Budda Baker led the defense in that game with 8 solo tackles and 0 assisted tackles while Dennis Gardeck led the defense in sacks with 3. No one on the defense came away with an interception for them in that one.

The current betting odds have the Cardinals listed as a 3 point underdog in this game according to Draftkings Sportsbook. The Cardinals have looked good in their games this season with their 1-1 record overall. They lost their season opener in Buffalo but they came out strong in that one before the defense let that game go. They looked a lot better last week though, the defense holding the Rams to just 10 points in a 41-10 win for the Cardinals in their home opener. The defense looked a lot better and the offense was rolling in that one with Murray and Harrison Jr on the same page the entire game. Meanwhile, the Lions also have a 1-1 record overall this season, but they haven't looked as good in their 2 games. Their 1 win came in their season opener against the Rams and that was a really close game for them at home which they needed overtime to win, even trailing late in the game. They didn't look great last week either, losing at home to the Buccaneers in a game where they were plagued by turnovers. Now the Lions play their 1st road game of the season and it is going to be tough to stop this Cardinals offense that has been rolling in both games. The defense also played a lot better at home last week so they are going to cause problems for this Lions offense that didn't take care of the ball last week. The Cardinals have the momentum from their huge divisional win last week and they are live to win this game outright. The best way to place a bet here is on the Cardinals to cover the spread in this game. 

Lions Cardinals Prediction:  Our NFL Pick for Sunday, September 22, 2024 (4:25 pm ET start time) is Cardinals 28 Lions 24.

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Detroit Lions: 27-12 ATS in all games. 13-5 ATS in road games. 7-0 ATS after a 2 game home stand. 23-16 OVER in all games. 15-8 OVER as a favorite. 6-1 OVER after a 2 game home stand. 

Arizona Cardinals: 2-7 1H ATS in a home game where the total is greater than or equal to 45.5. 0-8 1H ATS after 1 or more consecutive wins. 11-5 OVER in home games. 6-3 OVER in a home game where the total is greater than or equal to 45.5. 

Detroit Lions:  G. Glasgow (OL) Injured - Knee. A. Anzalone (LB) Injured - Concussion. A. St. Brown (WR) Injured - Quad. T. Arnold (CB) Injured - Illness. E. Rakestraw (CB) Injured - Hamstring. I. Williams (WR) Injured - Abdomen. M. Davenport (DL) Injured - Groin. K. Joseph (SAF) Injured - Back. I. Melifonwu (SAF) Injured - Ankle.

Arizona Cardinals:  W. Hernandez (OL) Injured - Ankle. D. Stills (DL) Injured - Shoulder. X. Weaver (WR) Injured - Oblique.

“I asked this team to improve and they improved, but the coach cost them the game. It is a massive error on my part. I messed up.” - Dan Campbell after his team’s loss against the Bucs in their last game. 

“He was lights out. He's a premium player for a reason. You take him against anybody. That's how I feel and that's what he did today.” - Jonathan Gannon on Kyler Murray after his team’s win against the LA Rams in their last game. 

WR Raymond, Kalif

WR Williams, Jameson

WR St. Brown, Amon-Ra

TE LaPorta, Sam 

QB Goff, Jared 

RB Gibbs, Jahmyr  

WR Wilson, Michael 

WR Harrison Jr., Marvin 

WR Dortch, Greg 

TE McBride, Trey 

QB Murray, Kyler 

RB Conner, James 

Passing: J. Goff (524)

Rushing: D. Montgomery (126)

Receiving: J. Williams (200)

Touchdowns: D. Montgomery (2)

Passing: K. Murray (428)

Rushing: J. Conner (172)

Receiving: M. Harrison (134)

Touchdowns: J. Conner (2)

Coaches:

Detroit Lions: Dan Campbell (4th season)

Arizona Cardinals: Jonathan Gannon (2nd season)