San Francisco 49ers vs Los Angeles Rams Prediction, Preview and Odds - 09/22/2024

Game Time: 4:25 pm ET, Sunday, September 22, 2024

Venue:  SoFi Stadium, Inglewood, CA

Where to Watch:  FOX

DraftKings:  Point Spread:  49ers -7, Rams +7; Over/Under:  44.5 points

Bet365:  Point Spread:  49ers -7, Rams +7; Over/Under:  44.5 points

BetMGM:  Point Spread:  49ers -7, Rams +7; Over/Under:  44.5 points

San Francisco 49ers:  1-1 (3rd place, NFC West)

Los Angeles Rams:  0-2 (4th place, NFC West)

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San Francisco 49ers:  lost their last game on the road against the Minnesota Vikings 23-17.

Los Angeles Rams:  lost their last game on the road against the Arizona Cardinals 41-10.

The 49ers are entering this game with a 1-1 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Minnesota Vikings 23-17. Brock Purdy was the starting QB and he completed 28/36 passes for 319 passing yards, 1 touchdown, and 1 interception. Jordan Mason led the team in rushing yards with 100 and 1 TD. Deebo Samuel Sr. led the receivers with 110 receiving yards on 8 receptions. Fred Warner led the defense in that game with 7 solo tackles and 2 assisted tackles while Nick Bosa led the defense in sacks with 2. Fred Warner came away with the only interception for them in that one.

 

 

 

The Rams are entering this game with a 0-2 record overall and they have a 0-1 record in their divisional games too. They are 0-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Arizona Cardinals 41-10. Matthew Stafford was the starting QB and he completed 19/27 passes for 216 passing yards, 0 touchdowns, and 0 interceptions. Blake Corum led the team in rushing yards with 28. Demarcus Robinson led the receivers with 50 receiving yards on 2 receptions. Quentin Lake led the defense in that game with 6 solo tackles and 5 assisted tackles while Kobie Turner led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have the 49ers listed as a 7 point favorite in this game according to Draftkings Sportsbook. The 49ers have a 1-1 record overall this season and they looked great in their season opener, but didn't look great last week. They won their season opener at home against the Jets, winning that game convincingly, but they lost their 1st road game of the season last week in Minnesota. They are on the road again here but playing on the road against the Rams has been more of a home game for the 49ers over the last few seasons. They will also be looking to bounce back from their loss and have still been really efficient on the ground, even without their star running back. Meanwhile, the Rams have looked terrible in their games this season with their 0-2 record overall. They lost their season opener on the road against the Lions in a really close game that went to OT, but they looked a lot worse on the road last week in their 41-10 loss to the Cardinals. That was the first loss ever for McVay in Arizona and even though this is their home opener, the Rams are dealing with a lot of injuries right now that have been hindering them. The 49ers didn't look great last week but Minnesota was a place they struggled in last season and they will be looking to bounce back here against a banged up team that they know well. The best way to place a bet here is on the 49ers to cover the spread in this game. 

49ers Rams Prediction:  Our NFL Pick for Sunday, September 22, 2024 (4:25 pm ET start time) is 49ers 31 Rams 17.

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San Francisco 49ers: 22-16 ATS as a favorite. 10-2 ATS versus division opponents. 6-3 UNDER after 1 or more consecutive losses. 6-2 UNDER off an upset loss as a favorite. 8-4 UNDER as a road favorite of 7 points or less.

Los Angeles Rams: 5-10 ATS in the first half of the season. 2-4 ATS after a loss by 14 or more points. 11-6 UNDER in the first half of the season. 4-1 UNDER off a loss against a division rival. 5-2 UNDER after a loss by 14 or more points.

San Francisco 49ers:  D. Samuel (WR) Injured - Calf. T. Hufanga (SAF) Injured - Knee. D. Winters (LB) Injured - Ankle.

Los Angeles Rams:  C. Kupp (WR) Injured - Ankle. J. Karty (K) Injured - Groin. K. Dotson (OL) Injured - Foot. D. Allen (TE) Injured - Back. C. Durant (DB) Injured - Toe.

"We never ask Brock to really do too much. We ask him to do the play that's called. If nothing's there, what are your options after that? You scramble, you throw things away. Sometimes you take a sack. Things you always try to do is not turn it over, but nothing really changes when you're missing guys. Game plan can sometimes change, but not what you ask the quarterback to do." - Kyle Shanahan on Brock Purdy after his team’s loss against the Vikings in their last game.

“There's not anything positive I can take from today. Anytime something like this occurs you've got to look inward first and foremost. Didn't do nearly a good enough job. There are so many things we have to go back and look at. It was an incredibly humbling three-hour window.” - Sean McVay after his team’s loss against the Cardinals in their last game. 

WR Aiyuk, Brandon

WR Conley, Chris

WR Jennings, Jauan

TE Kittle, George

QB Purdy, Brock 

RB Mason, Jordan 

FB Juszczyk, Kyle 

WR Robinson, Demarcus 

WR Johnson, Tyler 

WR Whittington, Jordan

TE Parkinson, Colby 

QB Stafford, Matthew 

RB Williams, Kyren

Passing: B. Purdy (550)

Rushing: J. Mason (247)

Receiving: D. Samuel (164)

Touchdowns: J. Mason (2)

Passing: M. Stafford (533)

Rushing: K. Williams (75)

Receiving: C. Kupp (147)

Touchdowns: K. Williams (2)

Coaches:

San Francisco 49ers: Kyle Shanahan (8th season)

Los Angeles Rams: Sean McVay (8th season)