Arizona Cardinals vs San Francisco 49ers Prediction, Preview and Odds - 10/06/2024

Game Time: 4:05 pm ET, Sunday, October 6, 2024

Venue:  Levi's Stadium, Santa Clara, CA

Where to Watch:  FOX

DraftKings:  Point Spread:  Cardinals +7, 49ers -7; Over/Under:  49.5 points

Bet365:  Point Spread:  Cardinals +7, 49ers -7; Over/Under:  49.5 points

BetMGM:  Point Spread:  Cardinals +7.5, 49ers -7.5; Over/Under:  49.5 points

Arizona Cardinals:  1-3 (3rd place, NFC West)

San Francisco 49ers:  2-2 (2nd place, NFC West)

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Arizona Cardinals:  lost their last game at home against the Washington Commanders 42-14.

San Francisco 49ers:  won their last game at home against the New England Patriots 30-13.

The Cardinals are entering this game with a 1-3 record overall and they have a 1-0 record in their divisional games too. They are 1-2 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Washington Commanders 42-14. Kyler Murray was the starting QB and he completed 16/22 passes for 142 passing yards, 1 touchdown, and 0 interceptions. James Conner led the team in rushing yards with 104 and 1 TD. Marvin Harrison Jr. led the receivers with 45 receiving yards on 5 receptions and 1 TD. Budda Baker led the defense in that game with 10 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. Garrett Williams came away with the only interception for them in that one.

 

 

 

The 49ers are entering this game with a 2-2 record overall and they have a 0-1 record in their divisional games too. They are 2-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the New England Patriots 30-13. Brock Purdy was the starting QB and he completed 15/27 passes for 288 passing yards, 1 touchdown, and 1 interception. Jordan Mason led the team in rushing yards with 123 and 1 TD. Jauan Jennings led the receivers with 88 receiving yards on 3 receptions. Ji'Ayir Brown led the defense in that game with 5 solo tackles and 3 assisted tackles while Kevin Givens led the defense in sacks with 2.5. Fred Warner came away with the only interception for them in that one.

The current betting odds have the 49ers listed as a 7 point favorite in this game according to Draftkings Sportsbook. The 49ers haven't looked great in their games this season with their 2-2 record overall, but they have looked great in their home games. They are 2-0 in their home games this season and they looked a lot better last week after losing 2 games in a row. They bounced back with a 30-13 win over the Patriots and they will be looking to get themselves back on track in the NFC West with a division win here at home. Meanwhile, the Cardinals haven't looked great in their games this season with their 1-3 record overall. Their only win came over the Rams, but now they have lost 2 games in a row. They looked terrible in their game last week too, getting embarrassed at home by the Commanders. The Cardinals have had a pretty good offense with Kyler Murray and the run game, but the defense has been terrible as they have been giving up a ton of points. That is going to be trouble in this game against a 49ers team with a really good offense. The 49ers will have no problem moving the ball against this defense at home and this is a much stronger defense for the Cardinals to go against, struggling against a bad Commanders defense last week. The best way to place a bet here is on the 49ers to cover the spread in this game. 

Cardinals 49ers Prediction:  Our NFL Pick for Sunday, October 6, 2024 (4:05 pm ET start time) is 49ers 38 Cardinals 17.

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Arizona Cardinals: 3-10 ATS versus division opponents. 3-7 ATS vs. good passing teams averaging 7 or more passing yards/att. 4-7 ATS vs. good offensive teams - scoring 24 or more points/game. 6-3 OVER after scoring 14 points or less last game. 10-4 OVER versus good offensive teams - averaging 350 yards/game or more. 9-3 OVER versus good rushing teams - averaging 130 rushing yards/game or more.

San Francisco 49ers: 10-3 ATS versus division opponents. 8-4 ATS when playing against a team with a losing record. 6-2 ATS versus poor rushing defenses - allowing 130 rushing yards/game or more. 16-7 OVER as a favorite of 3.5 to 9.5 points. 10-4 OVER versus division opponents. 12-5 OVER off a home win.

Arizona Cardinals:  I. Adams (OL) Questionable - Thumb. B. Baker (SAF) Injured - Quadricep. D. Gardeck (OLB) Injured - Finger. K. Tonga (DL) Out - Knee. T. McBride (TE) Out - Concussion. M. Harrison (WR) Injured - Quadricep. K. Beachum (OL) Questionable - Hamstring. D. Stills (DL) Injured - Shoulder.

San Francisco 49ers:  T. Hufanga (SAF) Questionable - Ankle. J. Elliott (DL) Questionable - Foot. C. Robinson (LB) Out - Knee. J. Cowing (WR) Injured - Illness. T. Williams (OT) Questionable - Illness. J. Hargrave (DL) Out - Triceps. B. Purdy (QB) Injured - Back. G. Kittle (TE) Injured - Hamstring. D. Samuel (WR) Questionable - Calf. D. Winters (LB) Questionable - Ankle.

“We can't look like that. Because we didn't give ourselves a chance to win the game.” - Jonathan Gannon after his team’s loss against the Commanders in their last game. 

“I saw him break out. I was getting hit so I was like, ‘I have to give my guy a shot here and give him a chance.’ I put it up for him. He made a great play, way better than the throw. He made the play.” - Brock Purdy after their win against the Patriots in their last game. 

WR Wilson, Michael 

WR Harrison Jr., Marvin 

WR Dortch, Greg 

TE Higgins, Elijah

QB Murray, Kyler 

RB Conner, James 

WR Aiyuk, Brandon

WR Samuel Sr., Deebo

WR Jennings, Jauan

TE Kittle, George

QB Purdy, Brock 

RB Mason, Jordan 

FB Juszczyk, Kyle 

Passing: K. Murray (777)

Rushing: J. Conner (293)

Receiving: M. Harrison (243)

Touchdowns: M. Harrison (4)

Passing: B. Purdy (1130)

Rushing: J. Mason (447)

Receiving: J. Jennings (364)

Touchdowns: J. Jennings (3)

Coaches:

Arizona Cardinals: Jonathan Gannon (2nd season)

San Francisco 49ers: Kyle Shanahan (8th season)